2003. As a parasitic fungal outbreak begins to ravage the country and the world, Joel Miller attempts to escape the escalating chaos with his daughter and brother. Twenty years later, a now hardened Joel and his partner Tess fight to survive under a totalitarian regime, while the insurgent Fireflies harbor a teenage girl with a unique gift.

In 2003, an Indonesian scientist makes a devastating discovery. In 2023, now outside of the quarantine zone, Joel and Tess clash over Ellie's fate as they navigate a long-abandoned Boston overrun with Infected.

Doomsday prepper Bill prepares to ride out the apocalypse alone...until a mysterious stranger upends his plans. Years later, Joel and Ellie seek Bill's guidance – and find themselves at a crossroads.

After a harrowing trek across a desolate United States, Joel and Ellie find themselves navigating a dangerous Kansas City on foot. Later, rebel leader Kathleen instigates a manhunt – one that pits her violent civilian militia against the world's best hope.

On the streets of a newly free Kansas City, Henry fights to protect his brother Sam from rebel soldiers who will stop at nothing to appease their ruthless leader. As her manhunt continues, Kathleen doubles down on her quest for revenge, while Ellie forms a meaningful friendship.