A seemingly routine murder investigation by the LAPD Robbery-Homicide Division is interrupted by the arrival of Deputy Chief Brenda Johnson, the new head of the LAPD’s Priority Murder Squad. An outsider from Atlanta in her first week of service, Brenda has already begun to face the resistance of long-time high-ranking officers and only her assistant, Sgt. Gabriel, seems willing to try to work with her.

Brenda and the team must investigate the murder of high-profile model Heather Kingsley, who dies as a result of nicotine poisoning. As Brenda investigates, she is drawn into the world of celebrity beauty, where illusion is everything, and the standard high.

Brenda must fight for justice for two Russian prostitutes murdered by the illegitimate son of a Russian mafia figure. As she does, she confronts her own prejudices, and discovers the justice for these women is scarce in a world dominated by men.

Brenda and the Priority Homicide Team investigate a sniper who is killing gang members in and around MacArthur Park. Offering assistance is an ex-Army colonel who believes the sniper to be his son. As an all-out gang war looms, Brenda tentatively accepts his assistance.

Brenda enters the high-stakes world of pharmaceutical research, when a drug trial for new anti-addiction medication lead to the death of one of the principal investigators. Nothing is quite as it seems as she investigates the high-powered president of the drug company sponsoring the trial, the seemingly easy-going psychiatrist and the teenaged participants in the study.

Brenda finds herself the unexpected victim of violence against women when she investigates the murder of a congresswoman's daughter. At first, it appears the victim was engaged in sexual activity online that included an invitation to violence.

A judge is murdered in Griffith Park and Brenda's investigation takes an unexpected twist when her best witness, or perhaps her prime suspect, is his teenage son with autism. Challenged by the boy's behaviors, but convinced he has the clue to unraveling the case, Brenda must try to understand him in order to learn what he knows.

When a gay man is murdered, seemingly the latest victim of a string of hate crimes, Brenda must confront prejudices inside and out of the LAPD. Meanwhile, Flynn and Taylor step up their efforts to undermine Brenda once again, but with unexpected effects, as the team begins to rally around Brenda.

The murder of an adolescent girl from Mexico, found dead in the Los Angeles River, proves difficult and painful for Brenda and her team. At first, a known sex-offender seems the likely candidate, but questions arise about why the girl and her mother were brought to the US, leading the investigation in another direction.

Three wealthy, spoiled and unruly children become the target of Brenda's investigation when their stepmother is murdered and the family butler seemingly commits suicide shortly thereafter. Riding heard on the trio is their family attorney, who cleans up their messes and provides them with alibis.

Brenda finds herself at odds with the FBI in a struggle to gain control of the murder investigation of a well-known businessman. Deciding to work in tandem, Brenda finds herself working directly with Fritz, who was assigned to the case.