While Kenshiro is at a bar, a group of rugged men appear and try to recruit him into their ranks. Kenshiro easily drives them off, but moments later, a grimy young boy walks into the bar. His name is Taki, a boy who once lived with Bat in a desolate village.

Toyo, a compassionate old woman, has taken in countless orphaned children and showers them with unconditional love. Kenshiro deeply respects her kindness, especially toward Bat and Rin, whom she treats no differently from the others. But after Kenshiro and his companions leave the village late at night, a terrible danger approaches.

Kenshiro burns with overwhelming fury at the monstrous cruelty Jackal inflicted on Toyo. Swearing he will have his revenge, he begins closing in on Jackal and his gang step by step. Driven into terror by Kenshiro's relentless pursuit, Jackal makes a desperate move-he frees "Devil Rebirth," a demonic giant who had been imprisoned in a penitentiary.

A woman appears before him: Mamiya, who bears a striking resemblance to his lost love, Yuria. Meanwhile, outside the village, a beautiful man-so striking he could be mistaken for a woman-roams the wasteland in search of the man marked with seven scars on his chest!!

Koh's life is taken by the Fang Clan, yet Mamiya stands firm before the villagers. But when she is alone, away from prying eyes, she quietly weeps for her fallen younger brother. Kenshiro and Rei set off in pursuit of the Fang Clan, who stole Koh's belongings as they fled...and now the fists of Hokuto and Nanto are about to explode!!

Fang Clan Chieftain discovers the whereabouts of Airi, the sister Rei has been searching for, and takes her hostage, using her as leverage to bend Rei to his will. When Rei finally reunites with his sister after so long, he is devastated by how much she has changed and loses control of himself. Watching Rei’s despair, Fang Clan Chieftain can barely contain his delight. Kenshiro tries desperately to calm Rei...but the situation spirals toward danger.

In the year 199X, the world was engulfed in nuclear fire!! Yet...humanity somehow survived!! A lone man with seven scars on his chest emerges. His name is Kenshiro, heir to Hokuto Shinken. In a world where only the strong survive, Kenshiro forges a path with his iron fists!