Ichika Orimura is attending the Infinite Stratos Academy as he is the first male to ever pilot an IS where he becomes a sensation among the all female students of the academy. With his homeroom teacher being his older sister Chifuyu, an ex-IS pilot, Ichika is in unease and unprepared and trying to get use to the academy. Later he learns his dorm roommate is his childhood friend, kendo champion Houki Sinonono, who he has not seen in six years. When his class decides to elect him as their class representative, the British cadet representative and noble, Cecilia Alcott is against it and challenges him to an IS duel for the position.

Ichika is told by Chifuyu that he will be provided with his own personal IS for his match against Cecilia, a rarity since there are only 467 IS Cores that were created by Tabane Shinonono, Houki's older sister before she disappeared. To prepare himself, Houki agrees to train Ichika by practicing Kendo. On the day of the match, Ichika is given the IS Byakushiki against Cecilia's IS, Blue Tears. Cecilia has the advantage at the beginning as her IS is a Sniper while Ichika IS is a Close-range fighter but Ichika manages to transform his IS into First Shift, the IS second form and pulls out an energy sword. Just as Ichika is about to strike Cecilia, the match is declared over and Cecilia the winner because Ichika's energy sword completely depleted his IS shields. Despite losing, Ichika agrees to train more with Houki while Cecilia is unsure of herself despite winning the match.

Cecilia takes a liking with Ichika and gives the position of class representative to him instead much to Houki's chargin. The next day, Ichika meets Lingyin, the new transfer student from China who also happens to be his childhood friend and also the class representative of her class. After Ichika and Lingyin get reacquainted with each other, Cecilia and Houki get jealous and coached Ichika in IS practice very hard. Upon learning Houki is Ichika's roommate, Lingyin tries to get Houki to let her become his roommate instead which Houki refuses. But Lingyin later leaves in anger after Ichika doesn't figure out the childhood promise they made and wants to settle it in the Inter-Class IS Tournament. With his match against Lingyin and her Shenlong IS next, Ichika prepares himself.

Ichika and Lingyin battle in the Inter-Class IS Tournament but their match is interrupted when a mysterious IS attacks the arena. As Ichika and Lingyin hold off the IS so the audience can escape, they soon realize the IS is an unmanned drone due to it's machine-like behavior. Together with Cecilia, the three of them manage to defeat the IS but not before it injures Ichika. As Ichika recovers while Lingyin watches over him, Ichika wonders the promise he made with Lingyin had a different meaning which the latter quickly denies. Meanwhile, Chifuyu and Maya examines the defeated IS and confirms it is an unmanned IS drone with a unique IS Core that didn't come from the 467 confirmed Cores the world has which makes them question who made it.

Houki has been given her own room by Maya and leaves in anger when Ichika is being dense about it but makes him promise to go out with her should she win the grade level individuals tournament, which spreads into a rumor that the winner of the tournament gets a date with Ichika. At the same time, a transfer student, another male IS pilot from France named Charles Dunois, arrives much to the joy of the girls of the Academy due to Charles's Bishōnen looks and "interest" with Ichika, who also becomes his new roommate. While Ichika's class has IS practice with Lingyin's class, Chifuyu has Lingyin and Cecilia battle against Maya in a Rafale Revive IS, a 2nd generation IS made by Charles' father's corporation, which Maya easily defeats Lingyin and Cecilia's more advanced ISs. While Ichika is having lunch with Houki, Lingyin, Cecilia and Charles, the girls try to give Ichika their lunches which he enjoys Houki's the most and feeds some of it to her much to the other girls' anger.