In a covert Romanian facility, Erik Heller evades security to rescue baby Hanna. 15 years on, father and daughter live deep in the Polish forest. Erik has trained Hanna to be an incredible killer and hunter. Yet, keen to grow beyond the boundaries of her isolated world, she begins to venture away from home. This attracts the attention of CIA agent Marissa Wiegler, who has hunted Hanna since birth.

Following her capture by Marissa's men, Hanna must fight to escape from the Moroccan CIA facility and join Erik in Berlin. Along the way, she meets Sophie, a British teenager on holiday with her family, who gives Hanna her first proper taste of the real world and the thrill of adolescence. Yet despite this glimpse at normality, the threat of Marissa and her operatives is never far behind.

Hanna and Erik are reunited in Berlin, where they hide out with his old army friends and she learns more about her father's past. However, Hanna continues to long for the normal life she glimpsed with Sophie and becomes increasingly frustrated at the restrictions her own father imposes on her. Sensing Marissa is closing in on them, Erik and his friends begin to prepare for an attack.