Beth, Annie and Ruby bite off more than they can chew when they agree to help Rio smuggle contraband. Ruby deals with a so-called family friend from her church and Annie prepares for a visit with a social worker that could help determine the fate of her custody battle with Greg.

Beth comes home to a surprise guest and is forced to confess to Ruby and Annie that she asked Rio if they could continue working for him. Meanwhile, Beth throws Kenny an elaborate birthday party, which unexpectedly leads the women to offer Rio a business proposition. Ruby's employment at the diner is threatened by a disgruntled teenage customer and Greg gives Annie the benefit of the doubt when she comes up with a creative solution for dealing with some bullies from Sadie's school.

With Dean back in the house, and her criminal activities expanding, Beth struggles to keep her new business separate from her home life. When Sadie goes on a trip, Annie's loneliness leads her to an ill-advised one-night stand. Ruby doubles down on her lies to Stan. FBI Agent Jim Turner follows up on Boomer's tip about the women.

Overwhelmed by the sheer volume of work their new enterprise demands, the ladies decide to outsource. While their business flourishes, the women's personal lives spiral: Dean confronts Beth about her association with Rio, Stan discovers Ruby's been lying to him about her employment at the diner, and Annie's conscience catches up with her.

Business is booming and the women are living large, but a threat from one of their employees reminds them how violent Rio can be when pushed and threatens everything they've been working toward. Meanwhile, Beth and Ruby both enjoy the shifting dynamics in their respective marriages. Boomer carries out a malicious plot against Annie that puts her fight for custody in jeopardy.

Rio’s feeling the heat from the FBI investigation, so he abruptly shuts down operations, cutting off Beth, Ruby, and Annie's money supply. Their attempt to go back to being ordinary housewives is short-lived when Mary Pat puts the financial squeeze on them -- forcing the three women to commit another heist.

Rio asks the women to complete a seemingly simple job so he can get the operation up and running, but Beth, Ruby, and Annie fear there may be more to the task than meets the eye. As the ladies’ long-simmering tensions with the gang leader boil over, Ruby learns that Sara has risen to the top of the transplant list.

Fearing for their lives, the ladies scramble to try to take down Rio. A kidney becomes available for Sara but Ruby and Stan don’t have the money to pay for it. The three women hatch a plan that will solve both problems – one that involves returning to the scene of their first crime.