When flight attendant Cassie Bowden meets passenger Alex Sokolov, she decides to spend an extravagant, very drunk night with him. But when she wakes up the next morning beside a dead body – and with no memory of what happened – Cassie fights to keep her wits about her long enough to make it back to New York, where more trouble looms.

Rattled by her own lies and under pressure from the FBI, Cassie goes against her lawyer best friend Annie's advice to lay low and tries to track down Alex's mysterious business associate Miranda - with bizarre and shocking results. After an unsettling meeting with Agents Hammond and White, Cassie meets the easy-going Buckley on a night out to forget her troubles.

Upon landing in Rome, Cassie deals with her sudden feelings of loss, and Megan confesses that she has secrets of her own. Back in New York, Cassie doubles down on finding Miranda by unceremoniously crashing Alex's memorial service. Searching for intel on the Sokolovs, Annie ambushes Alex's former colleague Sabrina and calls in a favor with a client.

Cassie follows a surprising paper trail to a suspiciously empty private jet service. Later, a visit from her brother Davey forces Cassie to confront her memories of her "unconventional" childhood.

With Miranda on her tail and the FBI closing in, Cassie enlists Max in a plan that involves breaking and entering, computer fraud, and too much vodka. Meanwhile, Annie is forced to repay an ominous favor to a client, and Megan's secrets threaten to come to light.